Custom Synthesis

A long track record in the manufacturing of organic electronic materials for: 

• Organic LED (OLED) for displays 

• Organic Photovoltaic (OPV) 

• Organic Photodetector (OPD) 

• Liquid crystal building blocks in high purity 

• Materials for batteries 

• Phosphorus-containing ligands and others (Large commercial and midsize scale) 

• Metallocenes and homogeneous catalysts 

• Pilot and midsize plants from 10 kg up to tons scale offering high flexibility 

• Advanced technologies: Low-temperature, e.g. for boronic acids and high pressure reactions for e.g. chiral compounds 

• Extended capacities for chemical process development at lab scale for contract research

• Process development for applications of bio-based materials 

• Applied technologies are hydrogenation, oxidation or purifications via rectification or crystallization 

• Piloting of new products 

• Manufacturing of test and tox quantities in a range of 100 kg up to tons per campaign 

• Large scale manufacturing at sites within the WeylChem network 

• Reactors from 10 to 100 liter constructed of glass, stainless steel and glass-lined steel and other materials as required 

• Distillation units 

• Thin film evaporators 

• Range of filtration units 

• Heating and cooling system 

• Vacuum drying cabinets 

• Option for direct connection to up and downstream units in the pilot plant at 300 to 500 liter 

Examples of key technologies used in large scale: 

• Acylation 

• Alkylation 

• Amination 

• Bromination 

• Carbonylation 

• Carboxylation 

• Chlorination 

• Chlorosulfonation 

• Cross coupling 

• Diazotization 

• Diels-Alder reaction 

• Friedel-Crafts reactions 

• Grignard reaction 

• Hartwig-Buchwald coupling 

• Heck reaction 

• Hydroformylation 

• Hydrogenation 

• Lithium alanate reduction 

• Melt reactions at high temperatures 

• Nitration 

• Organometallic reactions, e. g. with BuLi or HexLi 

• Organophosphorus chemistry 

• Polymerization or polycondensation 

• Reductive amination 

• Sodium boro-hydride reduction 

• Sulfonation (also with oleum) 

• Suzuki coupling 

• Ullmann reaction 

Capabilities 

• Advanced reactors with capacities of 100 l, 500 l and 1000 l can be operated via a heating/cooling circuit with an inert heat-transfer medium in the range from -100 °C to +200 °C. 

• Air-sensitive raw materials (e.g. Grignard-, butyl lithium-, lithium alanate-solutions, etc.) are metered from safety boxes. The reactors are DCS-controlled and equipped with on-site operator terminals. If required, they can quickly be linked to a number of conventional upstream and downstream reactors: 

Products 

• Various specialty chemicals including  

• Complex aldehydes 

• Organic boronic acids 

• Coupled aromatic ring systems  

• Homogenous catalysts 

• Building blocks for API-synthesis and materials for organic electronic 

Capabilities 

• Reactions including hydroformylations, carbonylations and hydrogenations performed in the presence of catalysts under high pressure to achieve the required conversion, selectivity and yield. 

• Special high-pressure autoclaves 

• 26 lab autoclaves of 0.2 to 1 liter up to 750 bar, 300 °C in different materials for process development 

• Piloting: 7 autoclaves from 5 to 300 liter up to 200 bar, 300 °C 

• Hastelloy up to 1.6 m³ (up to 200 bar, 200 °C) 

• Stainless steel up to 1.8 m³ (up to 100 bar) 

• Compressors and gas-supply stations 

• Carbon monoxide 

• Ethylene and Hydrogen from pipeline 

• Pre-formation and handling of air-sensitive homogenous catalysts 

Products 

• Enantiomeric alcohols (e.g. based on ketones) 

• Carboxylic acid esters and amides 

Flexible, variably connectable equipment for complex multi-stage synthesis 

• Total stirred reactor capacity >50 m3 

• 80 different reaction vessels from 0.1 up to 5.0 m3 

• Stirred pressure filters up to 4 m2 

• Thin film evaporators up to 1.0 m2 

• Short path evaporators up to 0.3 m2 

• Distillation columns up to 30 theoretical plates 

• Materials: Stainless steel, glass-lined steel, Hastelloy, glass